LeukoStor™ : Store and transport your leukapheresis material
WHY CHOOSE LEUKOSTOR?
Preserve your leukapheresis material for up to 5 days.
Move your samples across the world whilst maintaining the viability, phenotype and function of key immune cell populations.
Your cells can be easily encapsulated, shipped and released in a cost-effective manner.
Available in a bag format and can be handled in a closed system
QUICK AND EASY TO USE
Encapsulate your sample by simply adding a gel concentrate to your leukapheresis material and transferring to a bag containing gelation beads. After a few minutes, the apheresis material with gel in situ and is ready for storage or shipment. When ready to be used a gentle Dissolution Buffer is added to dissolve the gel, the beads are filtered out and the apheresis material ready to use.
ENCAPSULATION PROCESS
PRODUCT CODE
COMPONENTS
UNITS
UNIT VOLUME
APHERESIS VOLUME TO ADD
LS - 30S-03
LS - 30S-06
LS - 30S-12
LS - 30S-24
LS - 30S-50
Bag A (5x Gel A)
Bag B (GelBase beads)
Bag C (Dissolution Buffer)
Blood administration set
Line clamps
Bag A (5x Gel A)
Bag B (GelBase beads)
Bag C (Dissolution Buffer)
Blood administration set
Line clamps
Bag A (5x Gel A)
Bag B (GelBase beads)
Bag C (Dissolution Buffer)
Blood administration set
Line clamps
Bag A (5x Gel A)
Bag B (GelBase beads)
Bag C (Dissolution Buffer)
Blood administration set
Line clamps
Bag A (5x Gel A)
Bag B (GelBase beads)
Bag C (Dissolution Buffer)
Blood administration set
Line clamps
3 bags
3 bags
3 bags
3 bags
9 units
6 bags
6 bags
6 bags
6 bags
18 units
12 bags
12 bags
12 bags
12 bags
36 units
24 bags
24 bags
24 bags
24 bags
72 units
50 bags
50 bags
50 bags
50 bags
150 units
7.5mL
30.0mL
45.0mL
-
-
7.5mL
30.0mL
45.0mL
-
-
7.5mL
30.0mL
45.0mL
-
-
7.5mL
30.0mL
45.0mL
-
-
7.5mL
30.0mL
45.0mL
-
-
30.0mL
-
-
-
-
30.0mL
-
-
-
-
30.0mL
-
-
-
-
30.0mL
-
-
-
-
30.0mL
-
-
-
-
APPLICATIONS
Preserve T cell viability
LeukoStor™ preserves T-cell yield and viability after 5 days of storage at 25°C. Left - Total T-cell yield (CD3+ cells as a % of total single CD45+ cells) at day 5 following storage was improved by LeukoStor compared to the no-gel control (NGC) which represented non-manipulated LRSC material. Right - The quality of T cells from leukocone material (used as an apheresis starting material surrogate) severely deteriorated when left unprotected over 5 days at 25°C.
Maintain leukocyte composition in apheresis
Assessment of cell composition of apheresis material after 5-day storage in LeukoStor™.
Post-rest recovery of PBMCs isolated from leukocone material
Post-rest recovery of PBMCs isolated from leukocone material after storage in LeukoStor for 5 days at 25C. LeukoStor improves the post-rest recovery, viability, and metabolic activity of PBMCs compared to the no-gel control.
RESOURCES
Whitepaper - Application of LeukoStor™ to CAR-T Cell Therapy Manufacturing
